HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylcarbamoyl Chloride → (S)-N,N-Dimethyl 2-[3-(1-pyrrolidinyl)-1-propynyl]-1-pyrrolidinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylcarbamoyl Chloride | HCID 6598 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | (R)-1-[3-(2-pyrrolidinyl)-2-propynyl]pyrrolidine | HCID 14730289 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-N,N-Dimethyl 2-[3-(1-pyrrolidinyl)-1-propynyl]-1-pyrrolidinecarboxamide | HCID 54116560 | — |
Reaction Steps
This compound was obtained following Example 51, Part A but substituting (S)-1-[3-(2-pyrrolidinyl)-2-propynyl]pyrrolidine for (R)-1-[3-(2-pyrrolidinyl)-2-propynyl]pyrrolidine and dimethyl carbamoyl chloride for acetic anhydride. [α]D -78° (c 1.13, MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05137905 |
| Source dataset | uspto-grants-1992_08 |
| ORD ID | ord-fded39f369b64e21bf98aad4cb309caf |
| Source note | uspto-grants-1992_08 |