反应详情

To 100 parts of a hydrochloric acid solution 6N were added 5.65 parts of methyl 4-(acetylamino)-2-ethoxy-5-nitrobenzoate and the whole was stirred and refluxed for 30 minutes. After cooling, the precipitated product was filtered off and crystallized from 80 parts of 2-propanol at 0° C. The product was filtered off and dried, yielding 1.9 parts (42.2%) of methyl 4-amino-2-ethoxy-5-nitrobenzoate; mp. 210° C.; (intermediate 33).

1. temperaturerefluxed for 30 minutes
2. temperatureAfter cooling
3. filtrationthe precipitated product was filtered off
4. customcrystallized from 80 parts of 2-propanol at 0° C
5. filtrationThe product was filtered off
6. customdried