反应详情

To a stirred solution of 4.1 parts of ethyl 4-amino-5-cyano-2-hydroxybenzoate in 40 parts of 2-propanone were added successively 2.52 parts of dimethyl sulfate and 4.1 parts of potassium carbonate. The whole was stirred and refluxed for 3 hours. The reaction mixture was filtered while hot and the filter-cake was washed with 2-propanone. The filtrate was evaporated and the solid residue was crystallized from 24 parts of 2-propanol, yielding 3.5 parts (79.5%) of ethyl 4-amino-5-cyano-2-methoxybenzoate; mp. 164.5° C. (intermediate 110).

1. temperaturerefluxed for 3 hours
2. filtrationThe reaction mixture was filtered while hot and the filter-cake
3. washwas washed with 2-propanone
4. customThe filtrate was evaporated
5. customthe solid residue was crystallized from 24 parts of 2-propanol