Hydrochloric Acid → HCID 67900435, compound

Participants

Reaction Steps

A mixture of 6-acetyl-4-(4-chlorophenyl)-2-(4-trifluoromethylphenylamino) -5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine monohydrochloride (1.6 g, 3.3 mmol) in 40 mL of aqueous 10% hydrochloric acid was heated to reflux for 60 hours. The mixture was cooled to room temperature and the resulting solid was collected by filtration and recrystallized from water to give 1.1 g (75%) of 4-(4-chlorophenyl)-2-(4-trifluoromethylphenylamino) -5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine monohydrochloride. m.p.>250° C. MS: 405 (MH+).

Provenance & Evidence