Hydrochloric Acid → HCID 67900435, compound

HRID 846817Notes

Reaction equation

HRID 846817 reaction equation
Cl.C([N:5]1[CH2:32][CH2:31][C:8]2[N:9]=[C:10]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=3)[N:11]=[C:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[C:7]=2[CH2:6]1)(=O)C.Cl>>[ClH:19].[Cl:19][C:16]1[CH:17]=[CH:18][C:13]([C:12]2[C:7]3[CH2:6][NH:5][CH2:32][CH2:31][C:8]=3[N:9]=[C:10]([NH:20][C:21]3[CH:22]=[CH:23][C:24]([C:27]([F:30])([F:28])[F:29])=[CH:25][CH:26]=3)[N:11]=2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67900647HCID 67900647, compound

Product 1

HCID 67900435HCID 67900435, compoundYield 151.1%

Procedure

A mixture of 6-acetyl-4-(4-chlorophenyl)-2-(4-trifluoromethylphenylamino) -5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine monohydrochloride (1.6 g, 3.3 mmol) in 40 mL of aqueous 10% hydrochloric acid was heated to reflux for 60 hours. The mixture was cooled to room temperature and the resulting solid was collected by filtration and recrystallized from water to give 1.1 g (75%) of 4-(4-chlorophenyl)-2-(4-trifluoromethylphenylamino) -5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine monohydrochloride. m.p.>250° C. MS: 405 (MH+).

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 60 hours
  3. filtrationthe resulting solid was collected by filtration
  4. customrecrystallized from water

Sources & evidence

ORD record
ord-d437985492db47ddb67aa49ce1c01047
Source dataset
uspto-grants-1992_08
Patent number
US05137890

Reaction notes

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