Benzyl Bromide → HCID 19883252, compound

HRID 846819Notes

Reaction equation

HRID 846819 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]3[CH2:21][NH:20][CH2:19][CH2:18][C:11]=3[N:12]=[C:13]([NH:15][CH2:16][CH3:17])[N:14]=2)=[CH:5][CH:4]=1.[CH2:22](Br)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[CH2:22]([N:20]1[CH2:19][CH2:18][C:11]2[N:12]=[C:13]([NH:15][CH2:16][CH3:17])[N:14]=[C:9]([C:6]3[CH:7]=[CH:8][C:3]([Cl:2])=[CH:4][CH:5]=3)[C:10]=2[CH2:21]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 19883233HCID 19883233, compound

Product 1

HCID 19883252HCID 19883252, compoundYield 27.2%

Procedure

The title compound was prepared as described in Example 5 starting with 4-(4-chlorophenyl)-2-ethylamino- 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride (1.1 g, 3.4 mmol) and benzyl bromide (0.4 mL, 3.4 mmol) to produce 0.35 g (27%) of 6-benzyl-4-(4- chlorophenyl)-2-ethylamino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine. m.p. 138°-141° C. MS: 379 (MH+).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-375e1184a5c048b192161add1c9badb9
Source dataset
uspto-grants-1992_08
Patent number
US05137890

Reaction notes

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