Iodoethane → HCID 9970456, compound

HRID 846822Notes

Reaction equation

HRID 846822 reaction equation
O.Cl.Cl.[NH2:4][C:5]1[N:6]=[C:7]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[C:8]2[CH2:14][NH:13][CH2:12][CH2:11][C:9]=2[N:10]=1.NC1N=[C:25](C2C=CC(F)=CC=2)[C:26]2CNCCC=2N=1.Cl.Cl.ICC>>[NH2:4][C:5]1[N:6]=[C:7]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[C:8]2[CH2:14][N:13]([CH2:25][CH3:26])[CH2:12][CH2:11][C:9]=2[N:10]=1

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 131717489HCID 131717489, compound

Product 1

HCID 9970456HCID 9970456, compoundYield 60.8%

Procedure

The title compound was prepared as described in Example 17 starting with 2-amino-4-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine dihydrochloride hemihydrate (1.8 g, 5.5 mmol) and iodoethane (0.4 mL, 5.5 mmol) to produce 0.91 g (48%) of 2-amino-4-(4-fluorophenyl)-6-ethyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine. m.p. 242°-243° C. MS: 273 (HM+). IR(KBr): 3301, 3132, 2575, 1626, 1604 cm-1. 1H NMR (DMSO-d6) ∂7.63 (m,2H), 7.19 (m,2H), 4.39-3.01 (m,8H), 1.25 (t,J=2.4 Hz, 2H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-9558fcb4b655438da7566c3c987ac95b
Source dataset
uspto-grants-1992_08
Patent number
US05137890

Reaction notes

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