1-Chloro-2-(diethylamine)ethane hydrochloride → HCID 19883256, compound

HRID 846826Notes

Reaction equation

HRID 846826 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:5]2[CH2:11][NH:10][CH2:9][CH2:8][C:6]=2[N:7]=1.[ClH:19].[CH2:20]([N:22]([CH2:25][CH2:26][Cl:27])[CH2:23][CH3:24])[CH3:21]>>[ClH:27].[ClH:19].[ClH:27].[NH2:1][C:2]1[N:3]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:5]2[CH2:11][N:10]([CH2:21][CH2:20][N:22]([CH2:25][CH3:26])[CH2:23][CH3:24])[CH2:9][CH2:8][C:6]=2[N:7]=1.[ClH:27].[ClH:27].[ClH:27].[NH2:1][C:2]1[N:3]=[C:4]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:5]2[CH:11]([CH2:21][CH2:20][N:22]([CH2:25][CH3:26])[CH2:23][CH3:24])[NH:10][CH2:9][CH2:8][C:6]=2[N:7]=1

Participants

4

Reactant 2

HCID 133631-Chloro-2-(diethylamine)ethane hydrochlorideHCID 10105870HCID 10105870, compound

Product 2

HCID 19883222HCID 19883222, compoundHCID 19883256HCID 19883256, compoundYield 74.1%

Procedure

The title compound was prepared as described in Example 17 starting with 2-amino-4-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (2.0 g, 8.2 mmol) and diethylaminoethylchloride hydrochloride (2.8 g, 16.4 mmol) to give 1.1 g (39%) of 2-amino-5-(2- diethylaminoethyl)-4-(4-fluorophenyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine trihydrochloride. m.p. 234°-236° C. MS: 343(MH+).

Sources & evidence

ORD record
ord-f3e9ef7f26384cb7bb553d40447bc375
Source dataset
uspto-grants-1992_08
Patent number
US05137890

Reaction notes

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