Hydrochloric Acid → HCID 57161399, compound

HRID 846868Notes

Reaction equation

HRID 846868 reaction equation
[CH:1]([C@H:4]1[C:9]([O:10]C)=[N:8][C@@:7]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)(C)[C:6]([O:20][CH3:21])=[N:5]1)([CH3:3])[CH3:2].Cl.[CH2:23](OCC)C>>[CH:1]([C@@:4]1([CH3:23])[C:9](=[O:10])[NH:8][C@H:7]([CH2:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:6]([O:20][CH3:21])=[N:5]1)([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl Ether2×HCID 10989847HCID 10989847, compound

Product 1

HCID 57161399HCID 57161399, compoundYield 69%

Procedure

1.44 g of (2S,5R)-2,5-dihydro-2-isopropyl-3,6-dimethoxy-5-benzyl-5-methylpyrazine in 30 ml of diethyl ether were treated at room temperature with 25 ml of 0.2N HCl in diethyl ether. After 2 h, the mixture was evaporated in vacuo. Distillation of the residue gave 0.94 g (69%) of crude (2S,5R)-2,5-dihydro-2-isopropyl-6-methoxy-5-benzyl-methyl-pyrazin-3-one, boiling point 170° C./0.005 Torr.

Workup

  1. customthe mixture was evaporated in vacuo
  2. distillationDistillation of the residue

Sources & evidence

ORD record
ord-5d6392e4a347477caa8b0af96a2d5a8c
Source dataset
uspto-grants-1992_08
Patent number
US05138071

Reaction notes

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