2-Hydroxymethyl-4-methoxymethyl-1,5-diisopropylbenzene → 2,4-Diisopropyl-5-ethoxymethyl-benzaldehyde

HRID 846881Notes

Reaction equation

HRID 846881 reaction equation
[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=C[CH:7]=1.[OH:12][CH2:13][C:14]1[CH:19]=[C:18]([CH2:20][O:21][CH3:22])[C:17]([CH:23]([CH3:25])[CH3:24])=[CH:16][C:15]=1[CH:26]([CH3:28])[CH3:27]>C(Cl)Cl>[CH:26]([C:15]1[CH:16]=[C:17]([CH:23]([CH3:24])[CH3:25])[C:18]([CH2:20][O:21][CH2:22][CH3:7])=[CH:19][C:14]=1[CH:13]=[O:12])([CH3:28])[CH3:27]

Participants

4

Reactant 2

HCID 148505462-Hydroxymethyl-4-methoxymethyl-1,5-diisopropylbenzeneHCID 178418287HCID 178418287, compound

Product 1

HCID 198843442,4-Diisopropyl-5-ethoxymethyl-benzaldehyde

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

17.2 g (80 mmol) of pyridinium chlorochromate are added to a solution of 15.7 g (66.5 mmol) of the compound from Example 4 in 300 ml of methylene chloride, the mixture is stirred overnight at room temperature, filtered with suction through kieselgur, washed with 200 ml of methylene chloride, and dried using sodium sulphate.

Workup

  1. filtrationfiltered with suction through kieselgur
  2. washwashed with 200 ml of methylene chloride
  3. customdried

Sources & evidence

ORD record
ord-bf5e4e558fd54aa5b737a0ce9623c346
Source dataset
uspto-grants-1992_08
Patent number
US05138090

Reaction notes

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