反应详情

To a solution of 972 mg (1.8 mM) of 3-(3-chloropropylsulfonylamino)-2-methoxy-1-octadecylcarbamoyloxypropane III a1 in 10 ml of methyl ethyl ketone is added 500 mg (3.38 mM) of sodium iodide and the mixture is refluxed for 3 hours with stirring. After the solvent is evaporated, the residue is purified by the column chromatography on silica gel with a n-hexane - ethyl acetate (1:1) mixture as an eluent. The product is recrystallized from chloroform-n-hexane to give 972 mg (1.54 mM) of 3-(3-iodopropylsulfonylamino)-2-methoxy-1-octadecylcarbamoyloxypropane II a1 in 86% yield.

1. temperaturethe mixture is refluxed for 3 hours
2. customAfter the solvent is evaporated
3. customthe residue is purified by the column chromatography on silica gel with a n-hexane - ethyl acetate (1:1) mixture as an eluent
4. customThe product is recrystallized from chloroform-n-hexane