HRID846962

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9256

Thiazole

C3H3NS

结构：CCCCCCCCCCCCCCCCCCNC(=O)OCC(CNS(=O)(=O)CCCI)OC

HCID14835021

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCCCCNC(=O)OCC(CNS(=O)(=O)CCCc1[nH+]ccs1)OC.[I-]

HCID67903047

未命名化合物

收率 55%

PROCEDURE

实验过程

A solution of 240 mg (0.38 mM) of 3-(3-iodopropylsulfonylamino)-2-methoxy-1-octadecylcarbamoyloxypropane in 2 ml of thiazole is stirred at 50° C. overnight. After thiazole is evaporated, the residue is recrystallized from dichloromethaneacetone to give 150 mg (0.209 mM) of 2-methoxy-1-octadecylcarbamoyloxy-3-(3-thiazoliopropylsulfonylamino)propane iodide Ia2 in 55% yield.

WORKUP

后处理

customAfter thiazole is evaporated
customthe residue is recrystallized from dichloromethaneacetone

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-efe4dbb978b94eb7a7dd5c110283b6ea
来源数据集: uspto-grants-1992_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05138067
来源说明: uspto-grants-1992_08

反应 SMILES

[I:1][CH2:2][CH2:3][CH2:4][S:5]([NH:8][CH2:9][CH:10]([O:34][CH3:35])[CH2:11][O:12][C:13](=[O:33])[NH:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])(=[O:7])=[O:6].[S:36]1[CH:40]=[CH:39][N:38]=[CH:37]1>>[I-:1].[CH3:35][O:34][CH:10]([CH2:9][NH:8][S:5]([CH2:4][CH2:3][CH2:2][C:37]1[S:36][CH:40]=[CH:39][NH+:38]=1)(=[O:7])=[O:6])[CH2:11][O:12][C:13](=[O:33])[NH:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]