1-Hexadecylthio-3-(3-iodopropylsulfonylamino)-2-methoxypropane → 3-(3-Iodopropylsulfonylamino)-2-methylcarbamoyloxy-1-octadecylcarbamoyloxypropane

HRID 846981Notes

Reaction equation

HRID 846981 reaction equation
Cl[CH2:2][CH2:3][CH2:4][S:5]([NH:8][CH2:9][CH:10]([O:34][C:35](=[O:38])[NH:36][CH3:37])[CH2:11][O:12][C:13](=[O:33])[NH:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])(=[O:7])=[O:6].C(SCC(OC(=O)NC)COC(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)CCCCCCCCCCCCCCC.C(SCC(OC)CNS(CCC[I:111])(=O)=O)CCCCCCCCCCCCCCC>>[I:111][CH2:2][CH2:3][CH2:4][S:5]([NH:8][CH2:9][CH:10]([O:34][C:35](=[O:38])[NH:36][CH3:37])[CH2:11][O:12][C:13](=[O:33])[NH:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])(=[O:7])=[O:6]

Participants

4

Reactant 3

HCID 148350231-Hexadecylthio-3-(3-iodopropylsulfonylamino)-2-methoxypropaneHCID 148350393-(3-Chloropropylsulfonylamino)-2-methylcarbamoyloxy-1-octadecylcarbamoyloxypropaneHCID 19884201HCID 19884201, compound

Product 1

HCID 156672933-(3-Iodopropylsulfonylamino)-2-methylcarbamoyloxy-1-octadecylcarbamoyloxypropane

Procedure

3-(3-Chloropropylsulfonylamino)-2-methylcarbamoyloxy-1-octadecylcarbamoyloxypropane III c2 is allowed to react and worked up by the same procedure as described in (5). m.p. 97°-99° C. The summary of the experimental condition and the physical data of the product are listed in the Table 8.

Workup

  1. customto react

Sources & evidence

ORD record
ord-681ae825374b46959d3857d1f8caef89
Source dataset
uspto-grants-1992_08
Patent number
US05138067

Reaction notes

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