HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium azide → 1-Azido-2-(2-benzoyloxypropan-1-yl)-3-hexadecylthiopropane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium azide | HCID 88163 | — |
| Reactant | 3-Azido-2-tert-butoxycarbonylamino-1-hexadecylthiopropane | HCID 14835095 | — |
| Reactant | 2-(2-Benzoyloxypropan-1-yl)-3-hexadecylthiopropanol methanesulfonate | HCID 53635267 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Azido-2-(2-benzoyloxypropan-1-yl)-3-hexadecylthiopropane | HCID 19884195 | 96.6% |
Reaction Steps
A mixture of the previously obtained 2-(2-benzoyloxypropan-1-yl)-3-n-hexadecylthiopropyl methanesulfonate m12a and 1.297 g (26.5 mM) of lithium azide in 50 ml of dimethylformamide is allowed to react by the same procedure as described in (53) and 1.291 g (96.6% yield) of the titled compound m12b is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05138067 |
| Source dataset | uspto-grants-1992_08 |
| ORD ID | ord-2830154dfc284b2190328ccf55019e08 |
| Source note | uspto-grants-1992_08 |