Benzene → HCID 14010457, compound

HRID 847122Notes

Reaction equation

HRID 847122 reaction equation
C1C=CC=CC=1.[Cl:7][C:8]1[CH:18]=[C:17]([Cl:19])[C:16]([Cl:20])=[CH:15][C:9]=1[O:10][CH2:11][C:12](Cl)=[O:13].[NH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1>C(N(CC)CC)C>[Cl:7][C:8]1[CH:18]=[C:17]([Cl:19])[C:16]([Cl:20])=[CH:15][C:9]=1[O:10][CH2:11][C:12]([NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1)=[O:13]

Participants

5

Reactant 3

HCID 241BenzeneHCID 104392-AminopyridineHCID 3027592,4,5-trichlorophenoxyacetyl chloride

Product 1

HCID 14010457HCID 14010457, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

After filling in a dry 250 ml flask respectively 150 ml of anhydrous benzene and 32.5 g (0.118 mol) of 2,4,5-trichlorophenoxyacetyl chloride synthesized in Example 14, 11 g (0.118 mol) of 2-aminopyridine was added with vigorous stirring, and then 8.1 ml of triethylamine was slowly dropped to be heated and refluxed for 2-3 hours, while the external temperature was maintained at 80°-90° C.

Workup

  1. customAfter filling in a dry 250 ml flask
  2. temperatureto be heated
  3. temperaturerefluxed for 2-3 hours, while the external temperature
  4. temperaturewas maintained at 80°-90° C.

Sources & evidence

ORD record
ord-db21de2a82c141c79b165d338e6f47a1
Source dataset
uspto-grants-1992_08
Patent number
US05139564

Reaction notes

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