Hydrochloric Acid → 5-Nitroso 6-hydroxy quinazolin

HRID 847128Notes

Reaction equation

HRID 847128 reaction equation
[N:1]([O-:3])=O.[Na+].[OH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][N:10]=[CH:9]2.Cl>O>[N:1]([C:7]1[C:6]([OH:5])=[CH:15][CH:14]=[C:13]2[C:8]=1[CH:9]=[N:10][CH:11]=[N:12]2)=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 589643Quinazolin-6-olHCID 23668193Sodium Nitrite

Product 1

HCID 148328765-Nitroso 6-hydroxy quinazolin

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

During one hour and while stirring, a solution of 0.14 mole of sodium nitrite in 30 ml water is added to a cold solution (0°-5° C.) of 0.14 mole of 6-hydroxy quinazolin, 12 ml concentrated hydrochloric acid and 50 ml distilled water. Stirring is continued for one hour. The 5-nitroso 6-hydroxy quinazolin (formula IV) is thus obtained as a yellow precipitate, which is washed with water, then dried.

Workup

  1. distillationdistilled water
  2. stirringStirring
  3. waitis continued for one hour

Sources & evidence

ORD record
ord-f4066ab5fb134534bad5a511fa67a814
Source dataset
uspto-grants-1992_08
Patent number
US05139707

Reaction notes

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