m-Chloroperbenzoic acid → HCID 11355678, compound
Reaction equation
[CH3:1][S:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1.ClC1C=CC=C(C(OO)=[O:19])C=1>C(Cl)Cl>[CH3:1][S:2]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1)=[O:19]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- -78 °C
Procedure
A stirred solution of 4-(methylthio)benzonitrile (Aldrich Chemical Co.) (36 mmol) in methylene chloride (50 mL) at -78° C. is treated dropwise with a slurry of m-chloroperbenzoic acid (36 mmol) in 50 mL of methylene chloride over a period of 30 minutes. The mixture is stirred an additional hour at -78° C. and then allowed to warm to room temperature. The reaction mixture is washed with 3N sodium hydroxide solution (50 mL), dried (magnesium sulfate) and concentrated at reduced pressure to obtain the title compound.
Workup
- temperatureto warm to room temperature
- washThe reaction mixture is washed with 3N sodium hydroxide solution (50 mL)
- dry with materialdried (magnesium sulfate)
- concentrationconcentrated at reduced pressure
Sources & evidence
- ORD record
- ord-8012227e183f4d11adef5cf2f572478b
- Source dataset
- uspto-grants-1992_08
- Patent number
- US05140026
Reaction notes
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