HCID 19882346, compound → HCID 19882368, compound

HRID 847149Notes

Reaction equation

HRID 847149 reaction equation
[N:1]1([CH2:7][CH2:8][N:9]=[S:10]([C:24]2[CH:29]=[CH:28][C:27]([N+:30]([O-])=O)=[CH:26][CH:25]=2)([CH2:12][CH2:13][CH2:14][CH2:15][O:16]CC2C=CC=CC=2)=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>C(O)C.[Pd]>[N:1]1([CH2:7][CH2:8][N:9]=[S:10]([CH2:12][CH2:13][CH2:14][CH2:15][OH:16])([C:24]2[CH:29]=[CH:28][C:27]([NH2:30])=[CH:26][CH:25]=2)=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 19882346HCID 19882346, compound

Product 1

HCID 19882368HCID 19882368, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of N-[2-(4-morpholinyl)ethyl]-S-(4-nitrophenyl)-S-[4-(phenylmethoxy)butyl]sulfoximine in ethanol is treated under nitrogen with 5% palladium on carbon catalyst and the mixture is subjected to catalytic hydrogenation on a Parr apparatus at 70° C. When hydrogen uptake ceases, the catalyst is removed by filtration and the filtrate concentrated to obtain the title compound.

Workup

  1. customis subjected to catalytic hydrogenation on a Parr apparatus at 70° C
  2. customWhen hydrogen uptake ceases, the catalyst is removed by filtration
  3. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-1ace1d09facf459589c06ee38ebc7611
Source dataset
uspto-grants-1992_08
Patent number
US05140026

Reaction notes

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