Hydrochloric Acid → HCID 136447356, compound

HRID 847185Notes

Reaction equation

HRID 847185 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[N:15]=[C:14]([C:16]3[N:17]=[CH:18][N:19](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[C:20]=3[CH3:21])[O:13][N:12]=2)=[CH:3]1.[ClH:41]>>[ClH:41].[CH3:21][C:20]1[NH:19][CH:18]=[N:17][C:16]=1[C:14]1[O:13][N:12]=[C:11]([C:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:2]([CH3:1])[CH:3]=2)[N:15]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 14773936HCID 14773936, compound

Product 1

HCID 136447356HCID 136447356, compound

Procedure

3-(1-Methyl-1H-indol-3-yl)-5-(5-methyl-1-triphenylmethyl-1H-imidazol-4-yl)-1,2,4-oxadiazole (1.1 g) was suspended in methanolic hydrogen chloride. The mixture was stirred for 30 minutes and was refrigerated for 6 h. The title compound was filtered yielding (0.5 g) as a white powder, m.p. 260°-262° C. Found: C, 57,02; H, 4.58; N, 22.07; C15H13N5O.HCl requires C, 57.06; H, 4.47; N, 22.19%; δH (360 MHz, DMSO-d6) 2.70 (3H, s, CH3), 3.92 (3H, s, N-CH3), 7.27 (1H, t, J=6.2 Hz, CH), 7.32 (1H, t, J=6.1 Hz, CH), 7.59 (1H, d, J=7.5 Hz, CH), 8.10 (1H, d, J=7.5 Hz, CH), 8.17 (1H, s, CH), 8.68 (1 H, s, CH); m/z 279 (M+, 70%).

Workup

  1. waitwas refrigerated for 6 h
  2. filtrationThe title compound was filtered
  3. customyielding (0.5 g) as a white powder, m.p. 260°-262° C

Sources & evidence

ORD record
ord-983c74f866ed419495e1f721ed0b7ad2
Source dataset
uspto-grants-1992_08
Patent number
US05140034

Reaction notes

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