Hydrochloric Acid → HCID 178478914, compound

Participants

Reaction Steps

3-(1-Methyl-1H-indol-3-yl)-5-[(1-triphenylmethyl-1H-imidazol-4-yl)methyl]-1,2,4-oxadiazole (1.25 g) was dissolved in methanolic hydrogen chloride solution (50 ml) and stirred at room temperature for 48 h. The title compound precipitated from solution as a white solid (0.92 g), m.p. 255°-257° C. Found: C, 56.95; H, 4.56; N, 21.99; Cl, 11.17; C15H13N5O.HCl requires C, 57.05; H, 4.47; N, 22.17; Cl, 11.22%; δH (360 MHz, DMSO-d6) 3.88 (3H, s, CH3), 4.61 (2H, s, CH2), 7.24 (1H, t, J=6.9 Hz, CH), 7.30 (1H, t, J=6.9 Hz, CH), 7.57 (1H, d, J=8.1 Hz, CH), 7.70 (1H, s, CH), 8.02 (1H, d, J,=7.4 Hz, CH), 8.10 (1H, s, CH), 9.10 (1H, s, CH); m/z 279 (M+, free base, 100%).

Provenance & Evidence