Hydrochloric Acid → HCID 178478914, compound

HRID 847186Notes

Reaction equation

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[N:15]=[C:14]([CH2:16][C:17]3[N:18]=[CH:19][N:20](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[CH:21]=3)[O:13][N:12]=2)=[CH:3]1.[ClH:41]>>[ClH:41].[NH:20]1[CH:21]=[C:17]([CH2:16][C:14]2[O:13][N:12]=[C:11]([C:4]3[C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[N:2]([CH3:1])[CH:3]=3)[N:15]=2)[N:18]=[CH:19]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 14773939HCID 14773939, compound

Product 1

HCID 178478914HCID 178478914, compound

Procedure

3-(1-Methyl-1H-indol-3-yl)-5-[(1-triphenylmethyl-1H-imidazol-4-yl)methyl]-1,2,4-oxadiazole (1.25 g) was dissolved in methanolic hydrogen chloride solution (50 ml) and stirred at room temperature for 48 h. The title compound precipitated from solution as a white solid (0.92 g), m.p. 255°-257° C. Found: C, 56.95; H, 4.56; N, 21.99; Cl, 11.17; C15H13N5O.HCl requires C, 57.05; H, 4.47; N, 22.17; Cl, 11.22%; δH (360 MHz, DMSO-d6) 3.88 (3H, s, CH3), 4.61 (2H, s, CH2), 7.24 (1H, t, J=6.9 Hz, CH), 7.30 (1H, t, J=6.9 Hz, CH), 7.57 (1H, d, J=8.1 Hz, CH), 7.70 (1H, s, CH), 8.02 (1H, d, J,=7.4 Hz, CH), 8.10 (1H, s, CH), 9.10 (1H, s, CH); m/z 279 (M+, free base, 100%).

Workup

customThe title compound precipitated from solution as a white solid (0.92 g), m.p. 255°-257° C

Sources & evidence

ORD record: ord-9c151894a3324fb38df69ebd08286f11
Source dataset: uspto-grants-1992_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05140034

Reaction notes

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