反应详情

To a solution of 2-(1-naphthoxy)acetic acid (2.26 g, 11.2 mmol) in benzene (20 mL) was added oxalyl chloride (5 mL, 57.3 mmol). The resulting mixture was heated at reflux for 30 min, then allowed to cool and concentrated under reduced pressure. The residue was dissolved in benzene, and to this was added aluminium chloride (1.83 g, 13.9 mmol). The resulting mixture was stirred at room temperature for 1 h, then poured into ice. The organic phase was separated and washed with saturated aqueous NaCl. Removal of the solvent in vacuo provided the title compound (1.74 g, 84%).

1. temperatureThe resulting mixture was heated
2. temperatureat reflux for 30 min
3. temperatureto cool
4. concentrationconcentrated under reduced pressure
5. dissolutionThe residue was dissolved in benzene
6. additionpoured into ice
7. customThe organic phase was separated
8. washwashed with saturated aqueous NaCl
9. customRemoval of the solvent in vacuo