N-Iodosuccinimide → HCID 15029852, compound

HRID 847255Notes

Reaction equation

HRID 847255 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH2:6][CH2:5]2.[I:12]N1C(=O)CCC1=O>CC#N>[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[I:12])[C:7](=[O:11])[CH2:6][CH2:5]2

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 2331475-Hydroxy-1-indanone

Product 1

HCID 15029852HCID 15029852, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

5-Hydroxy-1-indanone (1.48 g), N-iodosuccinimide (2.25 g) and CH3CN (20 ml) were stirred at room temperature overnight. The solution was evaporated to dryness, slurried with EtOAc, then filtered. The filtrate was evaporated to dryness and the solid recrystallized from CH3CN affording the desired compound (0.92 g), m.p. 114°-15° C.

Workup

  1. customThe solution was evaporated to dryness
  2. filtrationfiltered
  3. customThe filtrate was evaporated to dryness
  4. customthe solid recrystallized from CH3CN affording the desired compound (0.92 g), m.p. 114°-15° C.

Sources & evidence

ORD record
ord-efb52517f643423d880d3e33032187f6
Source dataset
uspto-grants-1992_08
Patent number
US05140040

Reaction notes

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