HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Thiophen-2-yl)pyrrolidin-2-one → 3-(Thiophen-2-yl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Thiophen-2-yl)pyrrolidin-2-one | HCID 11159539 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(Thiophen-2-yl)pyrrolidine | HCID 15029907 | — |
Reaction Steps
To a suspension of LiAlH4 (0.46 g) in THF (25 ml) was added the product of Example 134 (1.0 g) in THF (30 ml). After the addition was complete the reaction was heated at reflux for 4 hrs.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05140040 |
| Source dataset | uspto-grants-1992_08 |
| ORD ID | ord-549a601d9e0748849215d1654ad4ae18 |
| Source note | uspto-grants-1992_08 |