4-(Thiophen-2-yl)pyrrolidin-2-one → 3-(Thiophen-2-yl)pyrrolidine

HRID 847262Notes

Reaction equation

HRID 847262 reaction equation
[H-].[H-].[H-].[H-].[Li+].[Al+3].[S:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[CH:12]1[CH2:16][NH:15][C:14](=O)[CH2:13]1>C1COCC1>[S:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[CH:12]1[CH2:13][CH2:14][NH:15][CH2:16]1

Participants

4

Reactant 2

HCID 111595394-(Thiophen-2-yl)pyrrolidin-2-oneHCID 21226445Aluminium lithium hydride

Product 1

HCID 150299073-(Thiophen-2-yl)pyrrolidine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a suspension of LiAlH4 (0.46 g) in THF (25 ml) was added the product of Example 134 (1.0 g) in THF (30 ml). After the addition was complete the reaction was heated at reflux for 4 hrs.

Workup

  1. additionAfter the addition
  2. temperaturewas heated
  3. temperatureat reflux for 4 hrs

Sources & evidence

ORD record
ord-549a601d9e0748849215d1654ad4ae18
Source dataset
uspto-grants-1992_08
Patent number
US05140040

Reaction notes

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