HuagongsheHuagongshe Chemistry Print Report · For research reference only
Testosterone → 17beta-Hydroxy-4-androstene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Testosterone | HCID 6013 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Trichloroacetic Acid | HCID 6421 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 17beta-Hydroxy-4-androstene | HCID 11022108 | 84.1% |
Reaction Steps
370 mg of anhydrous sodium borohydride is added in portions with ice/water cooling to 5 ml of trichloroacetic acid and 5 ml of acetonitrile. Then, 500 mg of 17beta-hydroxy-4-androsten-3-one in 9 ml of methylene chloride is instilled. It is stirred at room temperature and is worked up after 30 minutes, as described in example 1. 400 mg of 4-androsten-17beta-ol with melting point 144°-147° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05140106 |
| Source dataset | uspto-grants-1992_08 |
| ORD ID | ord-7c244cfd823d4a4baff81a5054dd6e5c |
| Source note | uspto-grants-1992_08 |