反应详情

370 mg of anhydrous sodium borohydride is added in portions with ice/water cooling to 5 ml of trichloroacetic acid and 5 ml of acetonitrile. Then, 500 mg of 17beta-hydroxy-4-androsten-3-one in 9 ml of methylene chloride is instilled. It is stirred at room temperature and is worked up after 30 minutes, as described in example 1. 400 mg of 4-androsten-17beta-ol with melting point 144°-147° C. is obtained.