Hydrochloric Acid → HCID 15106469, compound

HRID 847290Notes

Reaction equation

HRID 847290 reaction equation
[O:1]1CCCO[CH:2]1[C:7]1[CH:19]=[CH:18][C:10]([O:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:9]([NH:20][C:21](=[O:39])[C:22]2[CH:27]=[CH:26][C:25]([O:28][CH2:29][CH2:30][CH2:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[CH:24][CH:23]=2)[CH:8]=1.Cl.O>CC(C)=O>[CH:2]([C:7]1[CH:19]=[CH:18][C:10]([O:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:9]([NH:20][C:21](=[O:39])[C:22]2[CH:27]=[CH:26][C:25]([O:28][CH2:29][CH2:30][CH2:31][CH2:32][C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)=[CH:24][CH:23]=2)[CH:8]=1)=[O:1]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 15106467HCID 15106467, compound

Product 1

HCID 15106469HCID 15106469, compoundYield 77.5%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

In 200 ml of acetone was dissolved 8.69 g of ethyl 4-(1,3-dioxan-2-yl)-2-[p-(4-phenylbutoxy)benzamido]phenoxyacetate obtained in Reference Example 41. To the solution was added 6 ml of 6% hydrochloric acid. The mixture was stirred at room temperature for 2 hours. After adding 30 ml of water thereto, the mixture was cooled and the precipitated crystals were taken by filtration, washed with 50% acetone to obtain 6.0 g of ethyl 4-formyl-2-[p-(4-phenylbutoxy)benzamido]phenoxyacetate.

Workup

  1. customobtained in Reference Example 41
  2. temperaturethe mixture was cooled
  3. filtrationthe precipitated crystals were taken by filtration
  4. washwashed with 50% acetone

Sources & evidence

ORD record
ord-b2956d9e3726488a985781952ed48cb4
Source dataset
uspto-grants-1992_08
Patent number
US05140046

Reaction notes

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