反应详情

A mixture of 13.4 g (0.1 mole) of 1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile, 22.5 g (0.1 mole) of N-iodosuccinimide and 5 mL of trifluoroacetic acid in 250 mL of acetic acid was heated to reflux under argon for 4 hrs. The reaction was cooled and filtered to remove the crystalline precipitated product which was washed with water and ether and air dried to give 22.3 g (86%) of the 5-iodopyridinone as dense, light yellow needles, mp 260-264.

1. temperaturewas heated
2. temperatureto reflux under argon for 4 hrs
3. temperatureThe reaction was cooled
4. filtrationfiltered
5. customto remove the crystalline precipitated product which
6. washwas washed with water and ether and air
7. customdried