HCID 15657729, compound → HCID 13202691, compound

HRID 847360Notes

Reaction equation

HRID 847360 reaction equation
[CH2:1]1[C@@H:14]2[C@@:5]([C:15]([OH:17])=[O:16])([C:6]3[C:11]([CH2:12][CH2:13]2)=[CH:10][CH:9]=[CH:8][CH:7]=3)[CH2:4][CH:3]=[CH:2]1>CO.[Pd]>[CH2:1]1[C@@H:14]2[C@@:5]([C:15]([OH:17])=[O:16])([C:6]3[C:11]([CH2:12][CH2:13]2)=[CH:10][CH:9]=[CH:8][CH:7]=3)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 15657729HCID 15657729, compound

Product 1

HCID 13202691HCID 13202691, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of the product from Example 4 (27.4 g, 0.120 mol) in methanol was hydrogenated over 5% palladium on carbon (2.5 g). The reaction mixture was concentrated to give the title compound (24.3 g, 88%) as a white solid mp 142°-144° C.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-9490bb7d891945de9fc09439c43f9e1b
Source dataset
uspto-grants-1992_08
Patent number
US05141934

Reaction notes

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