反应详情

温度

70 °C

A mixture of 1 g of dl-5-chloro-6-ethyl-4-(α-ethyl-4-hydroxybenzylamino)pyrimidine, 1 g of perfluorotoluene, 0.24 g of powdery potassium hydroxide and 20 ml of 1,3-dimethyl-2-imidazolidinone (DMI) was heated under stirring at 70° C. for 8 hours. After completion of the reaction, the reaction mixture was poured into water, and extracted with toluene. The extract was washed with water, dried over anhydrous sodium sulfate and then toluene was evaporated under reduced pressure. The oily product obtained was isolated by column chromatography (Wako gel C-200, eluted with toluene:ethyl acetate=30:1) to give 1.5 g of the desired product as colorless crystals.

1. temperaturewas heated
2. customAfter completion of the reaction
3. extractionextracted with toluene
4. washThe extract was washed with water
5. dry with materialdried over anhydrous sodium sulfate
6. customtoluene was evaporated under reduced pressure
7. customThe oily product obtained