Methyl iodide → HCID 19881133, compound

HRID 847394Notes

Reaction equation

HRID 847394 reaction equation
[CH3:1][N:2]([CH3:17])[CH2:3][CH2:4][N:5]1[CH2:11][CH2:10][CH2:9][C:8]2[S:12][C:13]([CH3:15])=[CH:14][C:7]=2[C:6]1=[O:16].C[I:19]>CC(C)=O>[I-:19].[CH3:15][C:13]1[S:12][C:8]2[CH2:9][CH2:10][CH2:11][N:5]([CH2:4][CH2:3][NH+:2]([CH3:17])[CH3:1])[C:6](=[O:16])[C:7]=2[CH:14]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 19881033HCID 19881033, compound

Product 1

HCID 19881133HCID 19881133, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 0.9 g of 5-(2-dimethylaminoethyl)-2-methyl-5,6,7,8-tetrahydro-4H-thieno[3,2-c]azepin-4-one in 30 ml of acetone was added 0.4 ml of methyl iodide at room temperature. After being allowed to stand 30 minutes, the precipitated crystals were collected by filtration and washed with acetone to give 1.1 g of N-[2-(5,6,7,8-tetrahydro-2-methyl-4-oxo-4H-thieno[3,2-c]azepin-5-yl)ethyl]-N,N-dimethylammonium iodide as white crystals, melting at 237°-239° C.

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. washwashed with acetone

Sources & evidence

ORD record
ord-6482b978c27242d48ede8ab4a487005b
Source dataset
uspto-grants-1992_08
Patent number
US05141930

Reaction notes

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