反应详情

To a solution of 8,9-dihydro-7-[(hydroxy)(5-methyl-1-trityl-1H-imidazol-4-yl)methyl]-10-methylpyrido[1,2-a]-indol-6(7H)-one (4.6 g) in acetic acid (92 ml) were added 10% palladium on carbon (2.3 g) and ammonium formate (7.89 g), and the mixture was refluxed gently for 3 hours. After being cooled, the catalyst was filtered off. The filtrate was evaporated, and diluted with water (50 ml) and diisopropyl ether (50 ml). Aqueous sodium hydroxide was added to neutralized the solution. Resulted precipitates were collected, and washed with water and diisopropyl ether successively, to give 8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]-indol-6(7H)-one (1.87 g).

1. temperaturethe mixture was refluxed gently for 3 hours
2. temperatureAfter being cooled
3. filtrationthe catalyst was filtered off
4. customThe filtrate was evaporated
5. additiondiluted with water (50 ml) and diisopropyl ether (50 ml)
6. additionAqueous sodium hydroxide was added
7. customResulted
8. customprecipitates
9. customwere collected
10. washwashed with water and diisopropyl ether successively