Isopropanol → HCID 10334592, compound

HRID 847524Notes

Reaction equation

HRID 847524 reaction equation
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:16])[C:12](=[CH2:15])[CH2:13][CH2:14][C:3]=12.[CH3:17][C:18]1[NH:19][CH:20]=[CH:21][N:22]=1.C(O)(C)C>O>[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:16])[CH:12]([CH2:15][N:19]3[CH:20]=[CH:21][N:22]=[C:18]3[CH3:17])[CH2:13][CH2:14][C:3]=12

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 127492-MethylimidazoleHCID 10465751HCID 10465751, compound

Product 1

HCID 10334592HCID 10334592, compoundYield 30.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 8,9-dihydro-10-methyl-7-methylenepyrido[1,2-a]indol-6(7H)-one (142 mg), 2-methylimidazole (180 mg), isopropyl alcohol (1 ml) and water (0.4 ml) was heated at 100° C. for 3 hours. The reaction mixture was purified by a procedure analogous to that of Example 74 to give 8,9-dihydro-10-methyl-7-[(2-methyl-1H-imidazol-1-yl)methyl]pyrido[1,2-a]indol-6(7H)-one (60 mg).

Workup

  1. customThe reaction mixture was purified by a procedure analogous to that of Example 74

Sources & evidence

ORD record
ord-672a5186aaf945e58e834f0de2350df2
Source dataset
uspto-grants-1992_08
Patent number
US05141945

Reaction notes

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