Methanol → HCID 54016559, compound

HRID 847527Notes

Reaction equation

[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:32])[C:12](=[CH:15][C:16]3[N:17]=[CH:18][N:19](S(C4C=CC(C)=CC=4)(=O)=O)[C:20]=3[CH3:21])[CH2:13][CH2:14][C:3]=12.O1CCCC1.CO.[OH-].[Na+]>O.C(O)(=O)C>[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:11](=[O:32])[C:12](=[CH:15][C:16]3[N:17]=[CH:18][NH:19][C:20]=3[CH3:21])[CH2:13][CH2:14][C:3]=12

Participants

Conditions

Temperature: 80 °C

Procedure

To a solution of 8,9-dihydro-10-methyl-7-[(5-methyl-1-tosyl-1H-imidazol-4-yl)methylene]pyrido[1,2-a]indol-6(7H)-one (1.0 g) in the mixture of tetrahydrofuran (10 ml) and methanol (10 ml) was added 2N-sodium hydroxide. The mixture was heated at 80° C. for 5 hours. After being cooled, the reaction mixture was neutralized with acetic acid, and added water (40 ml). The precipitates were filtered to give 8,9-dihydro-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methylene]pyrido[1,2-a]indol-6(7H)-one (0.5 g).

Workup

temperatureAfter being cooled
filtrationThe precipitates were filtered

Sources & evidence

ORD record: ord-ae88541da5ad4ee09b40788de735b252
Source dataset: uspto-grants-1992_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05141945

Reaction notes

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