3-chloro-4-(trifluoromethoxy)benzamide → 3-chloro-4-(trifluoromethoxy)benzonitrile

Participants

Reaction Steps

750 ml of SOCl2 were added to 239.5 g (1 mole) of 3-chloro-4-trifluoromethoxy-benzamide and the mixture was slowly heated (according to the evolution of gas) to 85° C. The mixture was then fractionally distilled and 189 g of product having a boiling point at 13 mbar of 96° C. and a melting point of 38° to 40° C. were obtained. This corresponds to a yield of 85% of theory.

Provenance & Evidence