Oxalyl chloride → HCID 22910224, compound

HRID 847598Notes

Reaction equation

HRID 847598 reaction equation
[CH3:1][CH:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6](=[O:20])[C:7]([F:19])([F:18])[CH:8]([OH:17])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C(Cl)(=O)C(Cl)=O>CS(C)=O>[CH3:1][CH:2]([CH3:21])[CH2:3][CH2:4][NH:5][C:6](=[O:20])[C:7]([F:18])([F:19])[C:8](=[O:17])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 22910065HCID 22910065, compound

Product 1

HCID 22910224HCID 22910224, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

According to the procedure of Thaisrivongs et. al. (J. Med. Chem., 1986, 29, 2080), the resultant compound of Example 46 was treated with dimethylsulfoxide and oxalyl chloride to give the desired compound.

Sources & evidence

ORD record
ord-c571a8633f4d4ffa9e08489623b63886
Source dataset
uspto-grants-1992_08
Patent number
US05142056

Reaction notes

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