Carbodiimide → 2,4-Bis-(N-((p-toluenesulfonyl)valinyl)amino)-1,5-diphenyl-3-hydroxypentane

HRID 847615Notes

Reaction equation

HRID 847615 reaction equation
N=C=N.[C:4]1([CH3:21])[CH:9]=[CH:8][C:7]([S:10]([NH:13][C@H:14]([C:18](O)=[O:19])[CH:15]([CH3:17])[CH3:16])(=[O:12])=[O:11])=[CH:6][CH:5]=1.Cl.[NH2:23][CH:24]([CH:32]([OH:59])[CH:33]([NH:41][C:42](=[O:58])[C@H:43]([CH:55]([CH3:57])[CH3:56])[NH:44][S:45]([C:48]1[CH:53]=[CH:52][C:51]([CH3:54])=[CH:50][CH:49]=1)(=[O:47])=[O:46])[CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[C:51]1([CH3:54])[CH:52]=[CH:53][C:48]([S:45]([NH:44][C@H:43]([C:42]([NH:41][CH:33]([CH:32]([OH:59])[CH:24]([NH:23][C:18](=[O:19])[C@H:14]([CH:15]([CH3:17])[CH3:16])[NH:13][S:10]([C:7]2[CH:8]=[CH:9][C:4]([CH3:21])=[CH:5][CH:6]=2)(=[O:12])=[O:11])[CH2:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)=[O:58])[CH:55]([CH3:57])[CH3:56])(=[O:46])=[O:47])=[CH:49][CH:50]=1

Participants

4

Reactant 3

HCID 160435CarbodiimideHCID 2249310Tosyl valineHCID 228455882-Amino-4-(N-((p-toluenesulfonyl)valinyl)amino)-1,5-diphenyl-3-hydroxypentane Hydrochloride

Product 1

HCID 228455702,4-Bis-(N-((p-toluenesulfonyl)valinyl)amino)-1,5-diphenyl-3-hydroxypentane

Procedure

According to the carbodiimide coupling procedure of Example 55, N-(p-toluenesulfonyl)valine was coupled to the resultant compound of Example 112 to give the desired compound.

Sources & evidence

ORD record
ord-40610826b2664dce9d71a7af0b9b4dd0
Source dataset
uspto-grants-1992_08
Patent number
US05142056

Reaction notes

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