Picolinic acid → (2S,3R,4R,5S)-2,5-Di-(N-((2-pyridinyl)carbonyl)amino)-3,4-dihydroxy-1,6-diphenylhexane

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Reaction Steps

Picolinic acid was coupled to the resultant compound of Example 171 using the carbodiimide coupling procedure described in Example 55 to provide, after chromatography on silica gel using 5% methanol in chloroform, 58 mg (60%) of the desired compound (Rf 0.6, 10% methanol in chloroform) as a white solid, m.p. 179°-184° C. Mass spectrum: (M+H)+ =511.

Provenance & Evidence