関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 反応物 | 2-Chloro-5-methoxypyrimidine | HCID 589058 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-Methoxy-2-piperazin-1-yl-pyrimidine hydrochloride | HCID 86686609 | 51.5% |
反応手順
1.5 g piperazine-1-carboxylic acid tert-butyl ester was added to 1.2 g 2-chlor-5-methoxy-pyrimidine and 2.2 mL triethylamine in 30 mL DMF. The reaction was stirred 6 days at 60° C. The solvent was removed and the residue was dissolved in dichlormethane and extracted with water. The organic layer was washed with a saturated sodiumchloride-solution and evaporated. The residue was purified by HPLC to give 957 mg desired product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08846948B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-ead407df16ec434db4c7c75237acbeef |
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| 出典メモ | uspto-grants-2014_09 |
|---|
