反应详情

温度

60 °C

1.5 g piperazine-1-carboxylic acid tert-butyl ester was added to 1.2 g 2-chlor-5-methoxy-pyrimidine and 2.2 mL triethylamine in 30 mL DMF. The reaction was stirred 6 days at 60° C. The solvent was removed and the residue was dissolved in dichlormethane and extracted with water. The organic layer was washed with a saturated sodiumchloride-solution and evaporated. The residue was purified by HPLC to give 957 mg desired product.

1. customThe solvent was removed
2. dissolutionthe residue was dissolved in dichlormethane
3. extractionextracted with water
4. washThe organic layer was washed with a saturated sodiumchloride-solution
5. customevaporated
6. customThe residue was purified by HPLC