Chloral → HCID 20566771, compound

HRID 847658Notes

Reaction equation

HRID 847658 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][C:5]([NH:7][CH2:8][CH2:9][OH:10])=[S:6].[O:11]=[CH:12][C:13]([Cl:16])([Cl:15])[Cl:14]>>[Cl:14][C:13]([Cl:16])([Cl:15])[CH:12]([N:4]([CH2:3][CH2:2][OH:1])[C:5]([N:7]([CH:12]([OH:11])[C:13]([Cl:16])([Cl:15])[Cl:14])[CH2:8][CH2:9][OH:10])=[S:6])[OH:11]

Participants

3

Reactant 2

HCID 6407ChloralHCID 22411782HCID 22411782, compound

Product 1

HCID 20566771HCID 20566771, compound

Conditions

Temperature
80 °C

Procedure

To 98.4 g (0.6 mole) of 1,3-bis(2-hydroxyethyl)-thiourea at 65° C. was slowly added 182 g (1.24 moles) of chloral while the temperature was maintained below 75° C. by means of external cooling. The reaction mixture was vigorously stirred and heated at 80° C. for 1 hour. On cooling 275 g of a viscous syrupy product was isolated.

Workup

  1. customat 65° C.
  2. temperaturewas maintained below 75° C. by means of external cooling
  3. customwas isolated

Sources & evidence

ORD record
ord-4dfb0bb55e5248d8b94b4fb74bc41409
Source dataset
uspto-grants-1981_10
Patent number
US04293454

Reaction notes

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