Urea → Urea, N-hexyl-

HRID 847659Notes

Reaction equation

[NH2:1][C:2]([NH2:4])=[O:3].[CH2:5](N)[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]>>[CH2:5]([NH:1][C:2]([NH2:4])=[O:3])[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

Participants

Reactant 2

HCID 1176Urea

HCID 8102Hexylamine

Product 1

HCID 75092Urea, N-hexyl-

Procedure

A mixture of 6.0 g (0.1 mole) of urea and 11.1 g (0.11 mole) of n-hexylamine was heated at 130°-135° C. for 4 hours to form monohexylurea. Without isolation, the reaction mixture was cooled to 70° C., and 31.0 g (0.21 mole) of chloral was slowly added while the temperature was maintained below 80° C. using external cooling. The reaction mixture was vigorously stirred and heated at 80°-85° C. for 1 hour. On cooling 43.9 g of a viscous syrupy product was isolated.

Workup

temperaturewas heated at 130°-135° C. for 4 hours

Sources & evidence

ORD record: ord-5a83aaedcd9f48f191baa70403e43803
Source dataset: uspto-grants-1981_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04293454

Reaction notes

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