Urea → HCID 22179648, compound

HRID 847660Notes

Reaction equation

[NH2:1][C:2]([NH2:4])=[O:3].N[CH2:6][CH2:7][CH2:8][CH2:9][OH:10]>>[OH:10][CH2:9][CH2:8][CH2:7][CH2:6][NH:1][C:2]([NH2:4])=[O:3]

Participants

Reactant 2

HCID 1176Urea

HCID 258684-Amino-1-butanol

Product 1

HCID 22179648HCID 22179648, compound

Procedure

A mixture of 6.0 g (0.1 mole) of urea and 9.8 g (0.11 mole) of 4-amino-1-butanol was heated at 130°-135° C. for 4 hours to form monohydroxybutylurea. Without isolation the reaction mixture was cooled to 70° C. and then 31.0 g (0.21 mole) of chloral was slowly added while the temperature was maintained below 80° C. using external cooling. The reaction mixture was vigorously stirred and heated at 80°-85° C. for 1 hour. On cooling 43 g of a viscous syrupy product was isolated.

Workup

temperaturewas heated at 130°-135° C. for 4 hours

Sources & evidence

ORD record: ord-0e14934d0582480381fdbb76bd2065d7
Source dataset: uspto-grants-1981_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04293454

Reaction notes

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