反应详情

4.5 g of KOH and 15 g of 4-hydroxy-4'-(2-methylbutoxy)-biphenyl are dissolved in 150 ml of a 1:1 water/ethanol mixture, the solution is raised to the boil and 9 g of 6-chloro-1-hexanol are slowly added dropwise, whilst stirring, after which the batch is refluxed for about 10 hours. When the reaction solution has cooled, it is acidified with HCl and the product is extracted with CHCl3 in a separating funnel. The CHCl3 is then stripped off and the crude product is recrystallized from ethanol (melting point 118° C.).

1. additionare slowly added dropwise
2. temperatureafter which the batch is refluxed for about 10 hours
3. temperatureWhen the reaction solution has cooled
4. extractionthe product is extracted with CHCl3 in a separating funnel
5. customthe crude product is recrystallized from ethanol (melting point 118° C.)