Hydrochloric Acid → HCID 20566724, compound

HRID 847662Notes

Reaction equation

HRID 847662 reaction equation
[OH-].[K+].[OH:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][CH:18]([CH3:21])[CH2:19][CH3:20])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.Cl[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][OH:29].Cl>O.C(O)C>[OH:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][CH:18]([CH3:21])[CH2:19][CH3:20])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 748286-Chloro-1-hexanolHCID 140938154'-(2-Methylbutoxy)(1,1'-biphenyl)-4-ol

Product 1

HCID 20566724HCID 20566724, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

4.5 g of KOH and 15 g of 4-hydroxy-4'-(2-methylbutoxy)-biphenyl are dissolved in 150 ml of a 1:1 water/ethanol mixture, the solution is raised to the boil and 9 g of 6-chloro-1-hexanol are slowly added dropwise, whilst stirring, after which the batch is refluxed for about 10 hours. When the reaction solution has cooled, it is acidified with HCl and the product is extracted with CHCl3 in a separating funnel. The CHCl3 is then stripped off and the crude product is recrystallized from ethanol (melting point 118° C.).

Workup

  1. additionare slowly added dropwise
  2. temperatureafter which the batch is refluxed for about 10 hours
  3. temperatureWhen the reaction solution has cooled
  4. extractionthe product is extracted with CHCl3 in a separating funnel
  5. customthe crude product is recrystallized from ethanol (melting point 118° C.)

Sources & evidence

ORD record
ord-da41286d10ae4b408a82c485b1a93ae0
Source dataset
uspto-grants-1981_10
Patent number
US04293435

Reaction notes

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