HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium → 2-[4-(4-Methoxy-phenyl)-2-phenyl-imidazol-1-yl]-1-(4-pyridin-2-yl-piperazin-1-yl)-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium | HCID 3028194 | — |
| Reactant | (Trimethylsilyl)amide | HCID 53627528 | — |
| Reactant | 2-Bromo-1-(4-pyridin-2-yl-piperazin-1-yl)-ethanone | HCID 63680031 | — |
| Reactant | HCID 178488774 | HCID 178488774 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-[4-(4-Methoxy-phenyl)-2-phenyl-imidazol-1-yl]-1-(4-pyridin-2-yl-piperazin-1-yl)-ethanone | HCID 71585610 | 64.8% |
Reaction Steps
250 μl 1 mol/L lithium his (trimethylsilyl) amide solution in THF was added to 29 mg 2-bromo-1-(4-pyridin-2-yl-piperazin-1-yl)-ethanone in 1 mL DMF. The mixture was stirred 10 min at RT and 28 mg 4-(4-methoxy-phenyl)-2-phenyl-1H-imidazole was added. The reaction was stirred 2 h at 60° C. The mixture was purified by HPLC to give 30 mg desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846948B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-3ffe7ad3ac3644b8b854a1e7af40ad10 |
| Source note | uspto-grants-2014_09 |