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HRID847764

反应详情

EQUATION

反应方程式

HRID 847764 的结构方程式

REACTANTS

反应物

4
结构：CCC(=O)O
HCID1032

未命名化合物

结构：NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1N
HCID17513

Acadesine

C9H14N4O5

结构：CCC(=O)OC[C@H]1O[C@@H](n2cnc(C(N)=O)c2N)[C@H](OC(=O)CC)[C@@H]1OC(=O)CC
HCID12876356

未命名化合物

结构：CCC(=O)OC[C@H]1O[C@@H](n2cnc(C#N)c2N)[C@H](OC(=O)CC)[C@@H]1OC(=O)CC
HCID12947521

未命名化合物

PRODUCTS

生成物

1
结构：N#Cc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1N
HCID10977550

未命名化合物

PROCEDURE

实验过程

A method according to claim 8, wherein 5-amino-1-β-D-ribofuranosylimidazole-4-carboxamide is reacted with a reactive derivative of propionic acid, the resulting 5-amino-1-(2,3,5-tri-O-propionyl-β-D-ribofuranosyl)-imidazole-4-carboxamide is dehydrated, the resulting 5-amino-1-(2,3,5-tri-O-propionyl-β-D-ribofuranosyl)imidazole-4-carbonitrile is treated to remove the propionyls to yield 5-amino-1-β-D-ribofuranosylimidazole-4-carbonitrile and the last mentioned compound is reacted with phenylguanidine in the presence of aniline to produce N2 -phenyl-2,6-diaminonebularine.

WORKUP

后处理

  1. customto remove the propionyls