Propionic Acid → 5-amino-1-beta-D-ribofuranosyl-4-cyanoimidazole

Participants

Reaction Steps

A method according to claim 8, wherein 5-amino-1-β-D-ribofuranosylimidazole-4-carboxamide is reacted with a reactive derivative of propionic acid, the resulting 5-amino-1-(2,3,5-tri-O-propionyl-β-D-ribofuranosyl)-imidazole-4-carboxamide is dehydrated, the resulting 5-amino-1-(2,3,5-tri-O-propionyl-β-D-ribofuranosyl)imidazole-4-carbonitrile is treated to remove the propionyls to yield 5-amino-1-β-D-ribofuranosylimidazole-4-carbonitrile and the last mentioned compound is reacted with phenylguanidine in the presence of aniline to produce N2 -phenyl-2,6-diaminonebularine.

Provenance & Evidence