HCID 70576832, compound → HCID 12939743, compound

HRID 847766Notes

Reaction equation

HRID 847766 reaction equation
Br.[NH:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[S:11][CH:12]([C:17](=[O:25])[C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)[CH2:13][C:14]([OH:16])=[O:15]>C([O-])(O)=O.[Na+]>[NH:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[S:11][CH:12]([C:17](=[O:25])[C:18]1[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=1)[CH2:13][C:14]([OH:16])=[O:15]

Participants

3

Reactant 1

HCID 70576832HCID 70576832, compound

Product 1

HCID 12939743HCID 12939743, compoundYield 81.6%

Reagents, catalysts & solvents 1

HCID 516892Sodium BicarbonateSolvent

Procedure

30 g of the 3-(imidazo[4,5-b]pyridine-2-ylthio)-3-(4-chlorobenzoyl)propionic acid hydrobromide obtained above are dissolved in a dilute NaHCO3 solution (25 g NaHCO3 in 800 ml water), and the solution is filtered and the filtrate acidified with acetic acid. The solid is collected, washed well with water and air dried, yielding 20 g of material. The solid is recrystallized from hot acetonitrile. The title compound decomposes at about 140° C.

Workup

  1. filtrationthe solution is filtered
  2. customThe solid is collected
  3. washwashed well with water and air
  4. customdried

Sources & evidence

ORD record
ord-72a653a017d34596906a2c6964b0f4a6
Source dataset
uspto-grants-1981_10
Patent number
US04293696

Reaction notes

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