Hydrazine hydrate (1:1) → HCID 20567388, compound

HRID 847784Notes

Reaction equation

HRID 847784 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:12]3=[C:13]([C:15](=[O:23])[C:16]([C:18](OCC)=[O:19])=[CH:17][N:11]3[CH:10]3[CH:5]2[CH2:6][CH2:7][CH2:8][CH2:9]3)[CH:14]=1.O.[NH2:25][NH2:26]>CO>[OH2:19].[F:1][C:2]1[CH:3]=[C:4]2[C:12]3=[C:13]([C:15](=[O:23])[C:16]([C:18]([NH:25][NH2:26])=[O:19])=[CH:17][N:11]3[CH:10]3[CH:5]2[CH2:6][CH2:7][CH2:8][CH2:9]3)[CH:14]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 12911914HCID 12911914, compound

Product 1

HCID 20567388HCID 20567388, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2 g of ethyl 2-fluoro-7a,8,9,10,11,11a-hexahydro-4-oxo-4H-pyrido[3,2,1-jk]carbazol-5-carboxylate was dissolved in 80 ml of methanol, and 5 ml of hydrazine hydrate was added thereto. The mixture was then heated while refluxing. The precipitated yellow needle crystals were separated by filtration, and recrystallized from ethanol to obtain 1.7 g of 2-fluoro-7a,8,9,10,11,11a-hexahydro-4-oxo-4H-pyrido[3,2,1-jk]carbazol-5-carbohydrazide monohydrate.

Workup

  1. temperatureThe mixture was then heated
  2. temperaturewhile refluxing
  3. customThe precipitated yellow needle crystals were separated by filtration
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-fe13b9eb967e43fdbad07113c54f1046
Source dataset
uspto-grants-1981_10
Patent number
US04293694

Reaction notes

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